Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes

Combinatorial and modular methods to synthesize small molecule modulators of protein activity have proven be powerful tools in the development new drug-like molecules. Over past decade, these methodologies been adapted toward utilization activity- affinity-based chemical probes, as well chemoproteomic profiling. In this review, we will discuss how like multicomponent reactions, DNA-encoded libraries, phage displays, others provide ways rapidly screen novel probes against proteins interest.